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Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing.
- Source :
-
Dental Materials . Jul2020, Vol. 36 Issue 7, p865-883. 19p. - Publication Year :
- 2020
-
Abstract
- • The composite filaments were successfully developed via melt-blending technique. • AMP-PEEK filaments can serve as feedstock for 3D printing of patient-specific implants. • The bioactivity of the composites significantly increased cell adhesion and proliferation. • AMP-PEEK facilitate in vivo osseointegration and suitable bone regeneration capabilities. The aim of this study was to develop bioactive and osseointegrable polyetheretherketone (PEEK)-based composite filaments melt-blended with novel amorphous magnesium phosphate (AMP) particles for 3D printing of dental and orthopedic implants. A series of materials and biological analyses of AMP-PEEK were performed. Thermal stability, thermogravimetric and differential scanning calorimetry curves of as-synthesized AMP were measured. Complex viscosity, elastic modulus and viscous modulus were determined using a rotational rheometer. In vitro bioactivity was analyzed using SBF immersion method. SEM, EDS and XRD were used to study the apatite-forming ability of the AMP-PEEK filaments. Mouse pre-osteoblasts (MC3T3-E1) were cultured and analyzed for cell viability, proliferation and gene expression. For in vivo analyses, bare PEEK was used as the control and 15AMP-PEEK was chosen based on its in vitro cell-related results. After 4 or 12 weeks, animals were euthanized, and the femurs were collected for micro-computed tomography (μ-CT) and histology. The collected findings confirmed the homogeneous dispersion of AMP particles within the PEEK matrix with no phase degradation. Rheological studies demonstrated that AMP-PEEK composites are good candidates for 3D printing by exhibiting high zero-shear and low infinite-shear viscosities. In vitro results revealed enhanced bioactivity and superior pre-osteoblast cell function in the case of AMP-PEEK composites as compared to bare PEEK. In vivo analyses further corroborated the enhanced osseointegration capacity for AMP-PEEK implants. Collectively, the present investigation demonstrated that AMP-PEEK composite filaments can serve as feedstock for 3D printing of orthopedic and dental implants due to enhanced bioactivity and osseointegration capacity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01095641
- Volume :
- 36
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Dental Materials
- Publication Type :
- Academic Journal
- Accession number :
- 143767316
- Full Text :
- https://doi.org/10.1016/j.dental.2020.04.008