Durational effect of particulate matter air pollution wave on hospital admissions for schizophrenia.

Short-term exposure to high level of ambient particulate matters (PM) concentrations has been linked with increased hospital admissions (HA) for schizophrenia. However, evidence is inconclusive about the added effect of multi-day exposure to high-level PM concentration on schizophrenia. This study aims to evaluate the durational effect of PM air pollution wave on schizophrenia. Data on daily HA for schizophrenia, PM (PM 2.5 and PM 10) and meteorological variables over the period of 2014–2017 was collected in Jining, Shandong, China. Air pollution wave of PM was defined as ≥2 or ≥3 or ≥4 consecutive days with PM concentration ≥90th or ≥92.5th or ≥95th or ≥97.5th percentiles, respectively. A time-series Poisson regression model with duration as the variable of interest was used to evaluate the associations of PM air pollution wave with HA for schizophrenia. A total of 14650 hospital admissions for schizophrenia were identified. Under various air pollution wave definitions, both PM 2.5 and PM 10 had significant adverse effects on schizophrenia HA. PM 2.5 wave defined as ≥2 consecutive days with concentration ≥90th, ≥92.5th, ≥95th and ≥97.5th percentile was associated with 4.8% (2.0%–7.6%), 4.9% (1.9%–7.9%), 5.5% (2.0%–9.2%), and 7.6% (2.9%–12.6%) increase of HA for schizophrenia at lag 6. PM 2.5 waves defined as ≥3 consecutive days with concentration ≥90th, ≥92.5th, ≥95th and ≥97.5th percentile respectively corresponded to 5.0% (2.3%–7.8%), 5.1% (1.9%–8.4%), 6.9% (3.0%–10.8%) and 12.0% (5.3%–19.1%) increases in HA for schizophrenia at lag 6. The most significant associations were observed on the sixth day in different lag models. PM air pollution wave was associated with increased risk of hospital admissions for schizophrenia, with stronger associations among married and female patients. • 12 definitions to explore durational effects of particulate matter air pollution waves. • Time-series study link particulate matters air pollution wave with schizophrenia. • Finding durational effects of particulate matter waves on schizophrenia independently from impacts of daily exposure. [ABSTRACT FROM AUTHOR]