3D-printed Titanium Prosthetic Reconstruction of the C2 Vertebra: Techniques and Outcomes of Three Consecutive Cases.

<bold>Study Design: </bold>Three patients were treated at our center with patient-specific three-dimensional (3D)-printed titanium prostheses for the reconstruction of structurally compromised C2 vertebrae.<bold>Objective: </bold>To describe our surgical and device design approach to these clinical scenarios and evaluate their outcomes.<bold>Summary Of Background Data: </bold>There are a limited but increasing number of case reports and series describing the use of 3D-printed prostheses for high cervical surgery.<bold>Methods: </bold>We have collated and reviewed three cases using patient-specific 3D-printed prostheses.<bold>Results: </bold>We report two cases arising from neoplastic destruction; one resulting from metastatic medullary thyroid carcinoma, and the other from multiple myeloma. We additionally describe a case of C2 compromise as a complication of rheumatoid arthritis. All patients included in this report achieved successful surgical outcomes and symptom relief without significant complication. Clinical and radiological follow-up has demonstrated good outcomes in all cases up to 14-months postprocedure.<bold>Conclusions: </bold>These cases describe successful use of custom 3D-printed prostheses for reconstruction of the anterior vertebral column through C2, and add to the emerging body of literature detailing the use of custom prostheses for complex spinal surgery.<bold>Level Of Evidence: </bold>4. [ABSTRACT FROM AUTHOR]