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Integrin-linked kinase: integrin’s mysterious partner
- Source :
-
Current Opinion in Cell Biology . Oct2004, Vol. 16 Issue 5, p565-571. 7p. - Publication Year :
- 2004
-
Abstract
- Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments. [Copyright &y& Elsevier]
- Subjects :
- *INTEGRINS
*GLYCOPROTEINS
*CELL adhesion molecules
*CELL migration
*CYTOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 09550674
- Volume :
- 16
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 14392270
- Full Text :
- https://doi.org/10.1016/j.ceb.2004.07.004