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Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report.

Authors :
Takimoto Sato, Michiko
Ikezawa, Yasuyuki
Sato, Mineyoshi
Suzuki, Akira
Kawai, Yasutaka
Source :
Molecular & Clinical Oncology. Jul2020, Vol. 13 Issue 1, p43-47. 5p.
Publication Year :
2020

Abstract

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer, accounting for 3% of all lung cancers. The prognosis is poor and the standard therapy has not been well established. Herein, we report a case of advanced LCNEC of the lung that responded to nivolumab. The patient was a 62-year old man with stage IVB LCNEC of the lung. The disease progressed following the administration of second-line chemotherapy, and he was treated with nivolumab 3 mg/kg as the third-line treatment. Although treatment was ceased after two cycles due to interstitial pneumonia, the disease remained stable for approximately six months under observation. There was no other adverse event related to nivolumab. Following patient mortality from tumor progression, PD-L1 expression was observed to be negative (tumor proportion score <1%) by a re-examination of the primary biopsy specimen. The case herein suggests that nivolumab may be a possible treatment option for LCNEC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20499450
Volume :
13
Issue :
1
Database :
Academic Search Index
Journal :
Molecular & Clinical Oncology
Publication Type :
Academic Journal
Accession number :
144218458
Full Text :
https://doi.org/10.3892/mco.2020.2045