A new voltammetric sensor and its application in pharmaceutical analysis for rutin.

A new and sensitive electrochemical sensor for rutin determination was developed based on cetyltrimethylammonium chloride (CTAC) functionalized graphene (Gr) and palladium nanoparticles (Pd) (CTAC-Gr-PdNPs) composite. Rutin displayed remarkably increased electrochemical activity on the CTAC-Gr-PdNPs composite modified electrode due to the synergistic effect of the large surface area and electrocatalytic activity of both Gr and Pd nanoparticles, which offers the feasibility for highly sensitive determination of rutin via electrochemistry. Under the optimal experimental conditions, the oxidation peak current of rutin was proportional to its concentration in the range of 2.0 × 10−8–1.0 × 10−6 mol L−1, and the limit of detection (LOD) was 5 nM (S/N = 3). The developed method was successfully applied to determine rutin in pharmaceuticals with satisfactory recoveries, which shows that the fabricated sensor has potential in pharmaceutical analysis. [ABSTRACT FROM AUTHOR]