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Oxa-[3+3] annulation of MBH-carbonates of propiolaldehydes with α-nitro/bromo ketones to access 2H-pyrans.
- Source :
-
Chemical Communications . 7/4/2020, Vol. 56 Issue 42, p7191-7194. 4p. - Publication Year :
- 2020
-
Abstract
- A novel alkyne-assisted annulation reaction of MBH-carbonates of propiolaldehydes with α-nitro/bromo ketones is reported, providing a facile synthesis of substituted 2H-pyrans in good yields. This reaction divulges the inimitable reactivity of the MBH-carbonates of propiolaldehydes as C3-synthons wherein the alkyne functionality promoted the reaction without participating in the oxa-[3+3] annulation. The obtained products, having alkyne and ester functionalities, allowed further annulations to generate diverse pyrano[3,4-c]pyran-1-ones. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANNULATION
*KETONES
*ESTERS
*CARBONATE minerals
*NITRO compounds
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 42
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 144320671
- Full Text :
- https://doi.org/10.1039/d0cc02947e