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Carbon black-chitosan film-based electrochemical sensor for losartan.
- Source :
-
Journal of Solid State Electrochemistry . Aug2020, Vol. 24 Issue 8, p1827-1834. 8p. - Publication Year :
- 2020
-
Abstract
- A novel electrochemical method for determination of losartan using a glassy carbon electrode modified with carbon black nanoparticles immobilized within a crosslinked chitosan film is proposed. The electrochemical behavior of losartan was investigated using cyclic voltammetry, which presented an irreversible oxidation peak at a potential of + 1.28 V vs. Ag/AgCl (3.0 mol L−1 KCl). The electroactivity of losartan on the modified electrode was significantly improved in terms of peak potential and peak current intensity comparatively to bare working electrode. Using square-wave voltammetry technique under optimized conditions, the modified electrode showed a linear response in the concentration range of 4.97 to 47.6 μmol L−1 with a limit of detection of 0.479 μmol L−1. The developed electrochemical method was successfully applied for the determination of losartan in pharmaceutical formulation samples, with results consistent with those obtained by a comparative UV-Vis spectrophotometric method at 95% confidence level. In addition, losartan quantification was also achieved at synthetic biological fluid samples. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14328488
- Volume :
- 24
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Solid State Electrochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 144384713
- Full Text :
- https://doi.org/10.1007/s10008-020-04541-1