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Long-Acting Cabotegravir Protects Macaques Against Repeated Penile Simian-Human Immunodeficiency Virus Exposures.
- Source :
-
Journal of Infectious Diseases . Aug2020, Vol. 222 Issue 3, p391-395. 5p. - Publication Year :
- 2020
-
Abstract
- We used a novel penile simian-human immunodeficiency virus (SHIV) transmission model to investigate whether long-acting cabotegravir (CAB LA) prevents penile SHIV acquisition in macaques. Twenty-two macaques were exposed to SHIV via the foreskin and urethra once weekly for 12 weeks. Of these, 6 received human-equivalent doses of CAB LA, 6 received oral emtricitabine/tenofovir disoproxil fumarate, and 10 were untreated. The efficacy of CAB LA was high (94.4%; 95% confidence interval, 58.2%-99.3%) and similar to that seen with oral emtricitabine/tenofovir disoproxil fumarate (94.0%; 55.1%-99.2%). The high efficacy of CAB LA in the penile transmission model supports extending the clinical advancement of CAB LA preexposure prophylaxis to heterosexual men. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MACAQUES
*IMMUNODEFICIENCY
*HETEROSEXUAL men
*CONFIDENCE intervals
*URETHRA
*RNA virus infections
*PYRIDINE
*BIOLOGICAL models
*RESEARCH
*HIV integrase inhibitors
*PENIS
*ANIMAL experimentation
*RESEARCH methodology
*EVALUATION research
*MEDICAL cooperation
*PREVENTIVE health services
*PRIMATES
*COMPARATIVE studies
*CHEMOPREVENTION
*INFECTIOUS disease transmission
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 222
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 144409215
- Full Text :
- https://doi.org/10.1093/infdis/jiaa095