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Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives.
- Source :
-
Chemical Communications . 7/14/2020, Vol. 56 Issue 55, p7549-7552. 4p. - Publication Year :
- 2020
-
Abstract
- A facile enzymatic modular assembly strategy for the preparative-scale synthesis of poly-N-acetyllactosamine (poly-LacNAc) glycans with varied lengths and designed sialylation and/or fucosylation patterns is described. These glycans were printed as a microarray to investigate their interactions with a panel of glycan binding proteins (GBPs). Binding affinities revealed that the avidity of GBPs could be largely affected by the length and the patterns of sialylation and fucosylation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FUCOSYLATION
*CARRIER proteins
*GLYCANS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 55
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 144481139
- Full Text :
- https://doi.org/10.1039/d0cc03268a