Less invasive surfactant administration: all that glitters is not gold.

Keywords: Surfactant; Intubation; Neonate; Prematurity; Respiratory distress syndrome; INSURE; MIST EN Surfactant Intubation Neonate Prematurity Respiratory distress syndrome INSURE MIST 1295 1296 2 07/13/20 20200801 NES 200801 See related article, 10.1007/s00431-020-03682-9 In the last decade, techniques supposed to provide a less invasive surfactant administration have been proposed to treat respiratory distress syndrome (RDS), and the interest in these methods has spread. However, the so-called less invasive surfactant administration (LISA) or minimally invasive surfactant treatment (MIST) techniques represent an example of unjustified enthusiasm, as there is a lack of physiopathological and biological background supporting their hypothetical benefits [[1]]. INSURE intubation-surfactant-extubation LISA invasive surfactant administration MIST minimally invasive surfactant treatment NIPPV noninvasive positive pressure ventilation RDS respiratory distress syndrome Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. [Extracted from the article]