Back to Search
Start Over
Decreased placental IL9 and IL9R in preeclampsia impair trophoblast cell proliferation, invasion, and angiogenesis.
- Source :
-
Hypertension in Pregnancy . Aug2020, Vol. 39 Issue 3, p228-235. 8p. 1 Chart, 5 Graphs. - Publication Year :
- 2020
-
Abstract
- <bold>Objective: </bold>Our study aimed to investigate IL9 and IL9R expression in preeclampsia and assess their effects on trophoblast biological behaviors.<bold>Methods: </bold>IL9 and IL9R expression of placenta tissue were evaluated by immunochemistry and q-PCR. Using transwell, CCK-8, and tubule formation assays measured invasion, proliferation and angiogenesis of trophoblast with adding IL9 or anti-IL9R antibody.<bold>Results: </bold>IL9 and IL9R levels were significantly decreased in preeclampsia. IL9 improved trophoblast activities. Blocking IL9/IL9R resulted in decreased proliferation, invasion, and tube-formation capability of trophoblast.<bold>Conclusions: </bold>IL9 and IL9R contribute to the pathogenesis of preeclampsia. IL9/IL9R signaling provides a new potential therapeutic target for preventing preeclampsia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10641955
- Volume :
- 39
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Hypertension in Pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- 144526170
- Full Text :
- https://doi.org/10.1080/10641955.2020.1754852