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Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework.
- Source :
-
CrystEngComm . 7/21/2020, Vol. 22 Issue 27, p4526-4530. 5p. - Publication Year :
- 2020
-
Abstract
- We elucidate two annealing assisted mechanochemical methods to achieve one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU) in the iron-based MIL-100 metal–organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL-100 systems derived from in situ manual and vortex grinding, where the former technique exhibits a slower drug release due to stronger guest–host interactions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *METAL-organic frameworks
*FLUOROURACIL
*DRUGS
Subjects
Details
- Language :
- English
- ISSN :
- 14668033
- Volume :
- 22
- Issue :
- 27
- Database :
- Academic Search Index
- Journal :
- CrystEngComm
- Publication Type :
- Academic Journal
- Accession number :
- 144551784
- Full Text :
- https://doi.org/10.1039/d0ce00638f