NOTCH-1 ACTIVATION-DEPENDENT AUTOPHAGY RESTORATION CONTRIBUTES TO THE PROTECTIVE EFFECT OF RESVERATROL ON CIGARETTE SMOKE-INDUCED ENDOTHELIAL APOPTOSIS.

B TYPE: b Abstract Publication B TOPIC: b Obstructive Lung Diseases B PURPOSE: b Our previous studies have validated Notch1 as an anti-apoptotic signaling in cigarette smoke (CS)-induced endothelial apoptosis. 3-MA treatment inhibited autophagy and aggravated CSE induced apoptosis, while rapamycin promoted autophagy, led to a decrease in cell apoptosis. [Extracted from the article]