Back to Search
Start Over
Fungicidal activity and molecular modeling of fusarubin analogues from Fusarium oxysporum.
- Source :
-
Toxicological & Environmental Chemistry . Jan-Apr2020, Vol. 102 Issue 1-4, p78-91. 14p. - Publication Year :
- 2020
-
Abstract
- Fusarubin analogues of Fusarium oxysporum f. sp. ciceris were investigated for antifungal activity in vitro against five soil borne phytopathogenic fungi. 3-O-Methyl-8-O-methyl-fusarubin was inhibitory towards S. sclerotiorum (EC50 0.33 mmol L−1) and Sclerotium rolfsii (EC50 0.38 mmol L−1). A structure–antifungal activity relationship of fusarubin analogues was established from their activity performance. Possible mechanism of action of these compounds was studied using molecular docking and simulations against three target enzymes which revealed receptor ligand binding affinity. Docking of 3-O-methyl-8-O-methyl-fusarubin into the succinate dehydrogenase site revealed formation of salt bridge, hydrogen bond, π–anion, π–alkyl, and Van der Waals interactions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02772248
- Volume :
- 102
- Issue :
- 1-4
- Database :
- Academic Search Index
- Journal :
- Toxicological & Environmental Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 144637278
- Full Text :
- https://doi.org/10.1080/02772248.2020.1770253