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Dietary habits and risk of hepatocellular carcinoma among hepatitis B surface antigen carriers: A prospective cohort study in China.
- Source :
-
Journal of Digestive Diseases . Jul2020, Vol. 21 Issue 7, p406-415. 10p. - Publication Year :
- 2020
-
Abstract
- Objective: In this prospective cohort study, we aimed to evaluate the association between dietary habits and the risk of developing hepatocellular carcinoma (HCC) in hepatitis B surface antigen (HBsAg)‐positive carriers in Qidong, an hepatitis B virus (HBV)‐epidemic area in China. Methods: A total of 3199 HBsAg carriers aged 30‐70 years in a prospective cohort in Qidong, China from 2007 to 2011 were included in the study. At baseline, all participants self‐reported their dietary habits in a questionnaire interview. A follow‐up check‐up was performed every 6 months to identify HCC cases until November 2017. Cox's regression analysis and an interaction analysis were performed to estimate the relative risks of HCC in terms of baseline diet. Results: Among 3199 HBsAg‐positive participants, 270 developed HCC (143.86/100 000 person‐years [PYs]). Compared with participants who rarely consume garlic, the risk of HCC in those who consumed it ≥ once per week decreased along with the increase in frequency (HR = 1.00, 0.90 and 0.62 in those who consumed it rarely vs those who consumed it 1‐6 times per week and ≥ 7 times per week, respectively). This study found a synergistic effect between garlic and tea consumption on the risk of HCC (P = 0.039 for a multiplicative interaction). Conclusions: HBsAg carriers should improve their diet. Regular consumption of garlic and tea drinking may reduce the HCC incidence in HBsAg carriers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17512972
- Volume :
- 21
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Digestive Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 144707211
- Full Text :
- https://doi.org/10.1111/1751-2980.12878