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Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET.
- Source :
-
Journal of Assisted Reproduction & Genetics . Jul2020, Vol. 37 Issue 7, p1703-1710. 8p. - Publication Year :
- 2020
-
Abstract
- Purpose: This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh+/−, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes. Methods: A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh+/−, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group. Results: Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively, P < 0.05) undergoing IVF insemination, the inv(9) adversely increasing the early miscarriage rate, either undergoing IVF (21.4% vs. 3.0%, P < 0.05) or ICSI (50.0% vs. 2.0%, P < 0.05) insemination, female carriers (23.08% vs. 2.87%, P < 0.05) or male carriers (44.44% vs. 2.87%, P < 0.05). For D/G groups, ICSI insemination may increase the implantation rate (44.8% vs. 23.69%, P < 0.05) and clinical pregnancy rate (78.6% vs. 40.65%, P < 0.05). 1/9/16qh+/− had no apparent adverse effect on the patient's clinical outcomes. Conclusions: Our study suggests that chromosome karyotype analysis is necessary for IVF patients in clinical practice; we should afford individual genetic counseling suggestion according to the polymorphism types. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10580468
- Volume :
- 37
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Assisted Reproduction & Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 144709506
- Full Text :
- https://doi.org/10.1007/s10815-020-01793-8