精神分裂症患者甘露糖结合凝集素基因启动子区多态性 及血清浓度的研究.

Objective: To explore the relationship between serum concentration of mannose binding lectin (MBL) and gene polymorphism of promoter region in schizophrenia and its role in immunopathology. Methods: From June 2018 to December 2018, 54 schizophrenics in our hospital were selected as the observation group, and 56 volunteers in our health examination center at the same period were selected as the normal control group. The polymorphism of H/L (-550bp G/C) and X/Y (-221bp C/G) promoter regions of MBL gene was analyzed by PCR-SSP, and the concentration of MBL in serum was detected by ELISA. Results: The serum MBL concentration in the observation group (1367.218± 1277.429) ng/ml was lower than that in the normal control group (1987.781± 976.748) ng/mL, the difference was statistically significant (P<0.05). The frequency of HY/HY genotype in the observation group was lower than the control group (P<0.05), and the frequency of HY/LY genotype was higher than the control group (P<0.05). The serum MBL concentration of HY/HY genotype in the observation group was significantly higher than HY/LX,LY/LX genotype (P<0.05). The serum MBL level of homozygous mutant in the promoter region of MBL gene in the observation group was no significant difference from that in the control group (P>0.05), but the difference of MBL level of MBL genotype heterozygotes was statistically significant (P<0.05). Conclusion: The low level of MBL in schizophrenics is related to the comprehensive regulation of each genotype in the promoter region of MBL gene. The low concentration of MBL is one of the molecular mechanisms for the retention or removal of CIC in schizophrenia. [ABSTRACT FROM AUTHOR]