Copper-catalyzed formation of indolizine derivatives via one-pot reactions of chalcones, benzyl bromides and pyridines.

The one-pot cascade reaction for the preparation of indolizine from a wide range of chalcone, pyridine and benzyl bromide via [3 + 2] cycloaddition/oxidative aromatization promoted by Cu(OAc) 2 has been developed. This convenient method don't need to isolate the intermediates and the desired products indolizines were obtained in moderate to high yield catalyzed by Cu(OAc) 2 in the presence of oxygen. Image 1 • a one-pot manner for synthesis of indolizines derivatives, without purifying or isolating the intermediates. • The reaction doesn't require the addition of starting materials stage by stage and no additional separation process was required. • It is a new method for the synthesis of the desired products indolizines in high yield with catalyzed by Cu(OAc) 2 in the presence of oxygen. [ABSTRACT FROM AUTHOR]