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Copper-catalyzed formation of indolizine derivatives via one-pot reactions of chalcones, benzyl bromides and pyridines.
- Source :
-
Tetrahedron . Aug2020, Vol. 76 Issue 33, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- The one-pot cascade reaction for the preparation of indolizine from a wide range of chalcone, pyridine and benzyl bromide via [3 + 2] cycloaddition/oxidative aromatization promoted by Cu(OAc) 2 has been developed. This convenient method don't need to isolate the intermediates and the desired products indolizines were obtained in moderate to high yield catalyzed by Cu(OAc) 2 in the presence of oxygen. Image 1 • a one-pot manner for synthesis of indolizines derivatives, without purifying or isolating the intermediates. • The reaction doesn't require the addition of starting materials stage by stage and no additional separation process was required. • It is a new method for the synthesis of the desired products indolizines in high yield with catalyzed by Cu(OAc) 2 in the presence of oxygen. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 76
- Issue :
- 33
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 144786087
- Full Text :
- https://doi.org/10.1016/j.tet.2020.131347