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An Efficient Strategy for the Synthesis of 1,6-Naphthyridine-2,5-dione Derivatives under Ultrasound Irradiation.
- Source :
-
Synlett . 2020, Vol. 31 Issue 13, p1313-1317. 5p. - Publication Year :
- 2020
-
Abstract
- A flexible and efficient three-component reaction has been established for the synthesis of bioactive 1,6-naphthyridine-2,5-diones by using low-cost and readily accessible aminopyridinones, aromatic aldehydes, and Meldrum's acid as starting materials. The main advantage of this synthetic method is that the yields of the resulting 1,6-naphthyridine-2,5-dione derivatives under ultrasound irradiation in water with acetic acid as catalyst are higher than those from the classical-heating method. The probable reaction mechanism indicates that the process involves a Knoevenagel condensation, Michael addition, and cyclization sequence. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 31
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 144798234
- Full Text :
- https://doi.org/10.1055/s-0040-1707469