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Red blood cell exchange in sickle cell disease patient with multiple alloantibodies.
- Source :
-
Asian Journal of Transfusion Science . Jan-Jun2020, Vol. 14 Issue 1, p70-73. 4p. 1 Chart. - Publication Year :
- 2020
-
Abstract
- There are several reports in medical literature about Red Cell Exchange (RCE) being routinely performed pre-operatively in sickle cell disease patients to provide immediate decrease in HbS concentration and prevent post-operative complications. We would like to present one such case of SCD who also had multiple allo-antibodies and had to undergo hemi-arthroplasty for avascular necrosis of head femur. Grouping and antibody screening was performed using column agglutination technique. 3-cell and 11- cell panel were used for antibody screening and identification, respectively. Automated RBC exchange was performed on apheresis machine Com.Tec using the standard PL1 kit (Fresenius Kabi, Germany). Multiple (anti-c, E) allo-antibodies were identified and successful pre-operative RCE was done with corresponding antigen-negative AHG compatible RBC units. Single RCE procedure reduced HbS concentration from 65% to 25%. The patient underwent uneventful hemi-arthroplasty and was discharged on post-operative day-7. Patient is on regular follow-up and continues to do well two months after the day of surgery. This is possibly the first case report from India, which illustrates successful automated RCE in a SCD patient with alloimmunization. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09736247
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Asian Journal of Transfusion Science
- Publication Type :
- Academic Journal
- Accession number :
- 144908501
- Full Text :
- https://doi.org/10.4103/ajts.AJTS_36_18