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Antibacterial silver-doped calcium phosphate synthesized by an enzymatic strategy for initial caries treatment.
- Source :
-
Ceramics International . Oct2020, Vol. 46 Issue 14, p22466-22473. 8p. - Publication Year :
- 2020
-
Abstract
- As a chronic and infectious disease, dental caries has become a part of the heavy burdens of individuals and society, which is featured with tooth mineral loss and mainly caused by oral bacteria. Anti-caries agent should be safe, and capable of both high bacterial inhibition and remineralization, yet very few ones can meet these requirements simultaneously. In this study, a silver-doped amorphous calcium phosphate (Ag-EACP) is prepared by a biomimetic enzymatic reaction, with the in vivo energy storage biomolecule adenosine triphosphate disodium (Na 2 ATP) as the phosphorus source. Ag-EACP has an amorphous phase, with high content of ATP. The doped silver in the form of Ag+ ion is stabilized against transformation, can help adjust the size of Ag-EACP. The Ag-EACP can effectively inhibit the growth of Streptococcus mutans and Lactobacillus acidophilus , two main cariogenic pathogens, both in planktonic and free states, and suppress the formation of bio-film. Moreover, this nanocomposite generates significant remineralization and micro-hardness recovery of initial caries lesion. Ag-EACP shows great anti-caries effects on initial caries lesions and is promising for caries prevention in dentistry. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02728842
- Volume :
- 46
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Ceramics International
- Publication Type :
- Academic Journal
- Accession number :
- 144995242
- Full Text :
- https://doi.org/10.1016/j.ceramint.2020.06.005