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New Modes for the Osmium-Catalyzed Oxidative Cyclization.
- Source :
-
Organic Letters . Mar2010, Vol. 12 Issue 5, p1060-1063. 4p. - Publication Year :
- 2010
-
Abstract
- The osmium-catalyzed oxidative cyclization of amino alcohol initiators formally derived from 1,4-dienes is an effective method for the construction of pyrrolidines, utilizing a novel reoxidant (4-nitropyridine N-oxide = NPNO). The cyclization of enantiopure syn- and anti-amino alcohols gives rise to enantiopure cis- and trans-2,5-disubstituted pyrrolidines, respectively. Moreover, the cyclization of bis-homoallylic amines bearing an exocyclic chelating group is shown to be a complementary method for trans-pyrrolidine formation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 12
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 145005720
- Full Text :
- https://doi.org/10.1021/ol100046a