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Metal‐Free, H2O2‐Mediated, Regioselective Direct C‐3 Hydroxylation of Imidazo[1,2‐a]pyridines via C(sp2)‐H Bond Functionalization.
- Source :
-
ChemistrySelect . 8/7/2020, Vol. 5 Issue 29, p9235-9239. 5p. - Publication Year :
- 2020
-
Abstract
- For the first time, a new, cost‐effective, metal‐free, H2O2 (50 % in water)‐mediated regioselective direct C‐3 hydroxylation of imidazo[1,2‐a]pyridines via C‐H bond functionalization is reported. This metal‐free C(sp2)‐O bond formation protocol is operationally simple and showed broad range of functional group tolerance and substrate affinity. To the best of our knowledge, this is the first report of imidazo[1,2‐a]pyridine‐3‐ols showing promising in vitro antioxidant activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROXYLATION
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 23656549
- Volume :
- 5
- Issue :
- 29
- Database :
- Academic Search Index
- Journal :
- ChemistrySelect
- Publication Type :
- Academic Journal
- Accession number :
- 145043483
- Full Text :
- https://doi.org/10.1002/slct.202002219