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Association of Serum Indoxyl Sulfate Levels with Skeletal Muscle Mass and Strength in Chronic Hemodialysis Patients: A 2-year Longitudinal Analysis.

Authors :
Lin, Yu-Li
Liu, Chin-Hung
Lai, Yu-Hsien
Wang, Chih-Hsien
Kuo, Chiu-Huang
Liou, Hung-Hsiang
Hsu, Bang-Gee
Source :
Calcified Tissue International. Sep2020, Vol. 107 Issue 3, p257-265. 9p.
Publication Year :
2020

Abstract

Sarcopenia is highly prevalent in patients undergoing chronic hemodialysis (HD). This study investigated the relationship among serum indoxyl sulfate (IS) levels, muscle mass, and strength in HD patients. A total of 108 HD patients were enrolled. Skeletal muscle mass and handgrip strength (HGS) were assessed, using bioimpedance analysis and a hand-held dynamometer, respectively. Skeletal muscle index (SMI) was defined as skeletal muscle mass/height2 (kg/m2). Serum IS, p-cresol sulfate (PCS), and trimethylamine N-oxide (TMAO) levels were determined using liquid chromatography–mass spectrometry. Patients were classified into two groups based on median serum IS values. HGS measurement was repeated after 2 years. Patients in the high IS group had longer HD duration and higher serum TMAO levels than those in the low IS group. Log-normalized IS level was negatively correlated with SMI (r = − 0.227; p = 0.018), but PCS and TMAO levels were not. Among 78 patients who completed 2-year follow-up, those in the high IS group (n = 41) showed greater absolute (− 2.48 kg versus − 0.25 kg, p = 0.035) and relative HGS loss (− 9.1% versus 1.4%, p = 0.036) than those in the low IS group, after adjustment for potential confounders. Indoxyl sulfate (IS) may play a significant role in uremic sarcopenia. Further large-scale studies are needed to confirm our preliminary findings. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0171967X
Volume :
107
Issue :
3
Database :
Academic Search Index
Journal :
Calcified Tissue International
Publication Type :
Academic Journal
Accession number :
145047873
Full Text :
https://doi.org/10.1007/s00223-020-00719-x