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STK11 mutation status is associated with decreased survival in meningiomas.
- Source :
-
Neurological Sciences . Sep2020, Vol. 41 Issue 9, p2585-2589. 5p. 2 Charts, 2 Graphs. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Emerging evidence suggests that STK11 mutations may influence clinical outcome and response to immunotherapy in cancer.<bold>Materials and Methods: </bold>Next-generation targeted sequencing of STK11 mutation status in a large cohort of 188 meningiomas.<bold>Results: </bold>STK11 loss-of-function mutations were identified in 3.7% of meningiomas. STK11 mutations were found in both low- and high-grade lesions and samples from primary and recurrent disease. There was a 2.8-fold increased risk of death for patients whose meningioma harbored an STK11 mutation, after controlling for lesion grade and occurrence status. The median overall survival for patients with STK11-mutated meningiomas was 4.4 years compared with 16.8 years.<bold>Conclusion: </bold>These data identify recurrent STK11 mutations in a subset of meningiomas. Genotyping of STK11 is encouraged for meningioma patients undergoing immunotherapy-based therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NUCLEOTIDE sequencing
*MENINGIOMA
Subjects
Details
- Language :
- English
- ISSN :
- 15901874
- Volume :
- 41
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Neurological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 145048633
- Full Text :
- https://doi.org/10.1007/s10072-020-04372-y