Distribution of Allotypic Specificities on the Peptide Chains of Human Gamma-Globulin.

The peptide chains (A and B) isolated from the 7S γ-globulin of a single donor known to be Gm(a+ b + ) and Inv(a + ), were tested for the presence of allotypic specificities. Gm factors were present only on the A chain and the Inv factor was found only on the B chain. Ten pathological B chains, of which five were antigenic type I and five type II, were studied; all were negative for Inv(a), but Inv(b) specificity appeared to be associated with B chains of both antigenic types. [ABSTRACT FROM AUTHOR]