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Antitumour properties based on the self‐assembly of camptothecin and carbamoylmannose conjugates.
- Source :
-
Chemical Biology & Drug Design . Aug2020, Vol. 96 Issue 2, p870-877. 8p. - Publication Year :
- 2020
-
Abstract
- Camptothecin (CPT) and its analogues show potent antitumour activity. However, poor water solubility and severe side effects have restricted their applications in clinical practice. In this paper, a novel self‐assembly based on camptothecin and carbamoylmannose conjugates (CPT‐Man) was constructed. The self‐assembly increased the water solubility of camptothecin to 0.64 mg/ml and antitumour activity. Moreover, CPT‐Man could induce obvious cancer cell apoptosis. This work provides a new approach for exploring carbohydrate‐modified antitumour properties by self‐assembled CPT drugs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *APOPTOSIS
*CANCER cells
*ALKALOIDS
*DRUG side effects
*CAMPTOTHECIN
Subjects
Details
- Language :
- English
- ISSN :
- 17470277
- Volume :
- 96
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Chemical Biology & Drug Design
- Publication Type :
- Academic Journal
- Accession number :
- 145234515
- Full Text :
- https://doi.org/10.1111/cbdd.13698