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Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2.
- Source :
-
Journal of Autism & Developmental Disorders . Sep2020, Vol. 50 Issue 9, p3276-3295. 20p. 8 Charts, 1 Graph. - Publication Year :
- 2020
-
Abstract
- We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a "triple criteria" diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01623257
- Volume :
- 50
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Autism & Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 145259458
- Full Text :
- https://doi.org/10.1007/s10803-019-04148-0