MG7-Ag 单检与PG、G-17、Hp 感染三者联合检测对胃癌诊断价值的 meta 分析.

Objective To investigate the diagnostic value of MG7-Ag single detection and the combination detection of PG, G-17 and helicobacter pylori(Hp)infection in gastric cancer. Methods The literatures about MG7-Ag single detection and the combination detetion of PG, G-17 and Hp infection in diagnosing gastric cancer were retrieved from the databases of PubMed, CNKI, Wan Fang and VIP databases, and the retrieval time was from the database establishment to September 2019. Two researchers independently screened the literatures, extracted the data according to inclusion and exclusion criteria, and used the QUADAS 2 tool in the Review Manager 5.3 software to conduct the quality evaluation on the obtained literatures. The gastroscopy and mucous membrane biopsy served as the golden standard. Specificity (SEN), specificity(SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the ROC curve (AUC) and relative diagnostic odds ratio of the above two methods were pooled respectively by adopting the Stata/SE 15.1 software. Results A total of 2 072 articles were retrieved and 22 articles were finally included, involving 7 166 patients.The pooled SEN, SPE, PLR, NLR, DOR and AUC of MG7-Ag single detection in diagnosing gastric cancer were 0.67 (95%CI:0.58-0.75), 0.91 (95%CI:0.89-0.93), 7.75 (95%CI:5.76-10.43), 0.36 (95%CI:0.28-0.47), 21.47 (95%CI:13.43-34.31) and 0.91 (95%CI:0.88-0.93)respectively;which of combination detection of PG, G-17 and Hp infection were 0.78 (95%CI:0.53-0.92), 0.92(95%CI:0.88-0.95), 10.20 (95%CI:6.78-15.37), 0.24 (95%CI:0.10-0.58), 43.10 (95%CI:16.54-112.32) and 0.94 (95%CI:0.92-0.96) respectively.Compared with MG7-Ag single detection, the relative diagnostic odds ratio of combination detection of PG, G-17 and Hp infection was 1.91 (95%CI:0.65-5.62). Conclusion The sensitivity of combination detection of PG, G-17 and Hp infection in diagnosing gastric cancer is better than the MG7-Ag single detection, and the other indicators have no obvious difference in the aspect of diagnostic value. [ABSTRACT FROM AUTHOR]