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Ultrasound-assisted self-assembly of β-cyclodextrin/debranched starch nanoparticles as promising carriers of tangeretin.
- Source :
-
Food Hydrocolloids . Nov2020, Vol. 108, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- In this study, a starch-based nanocarrier was fabricated to allow tangeretin to avoid the disadvantages of poor aqueous solubility and weak stability. A green technique comprised of a combination of ultrasonication and recrystallization was applied, which ensured the products would be more applicable in the food, pharmaceutical, and cosmetic industries. Debranched starch (DBS) and β-cyclodextrin (β-CD) underwent ultrasonic irradiation and were self-assembled at 4 °C to form CD/DBS-nanoparticles (NPs). By developing CD/DBS-NPs with different degrees of polymerization of DBS and under varied durations of ultrasonic irradiation, the correlation between particle construction and tangeretin loading ability of CD/DBS-NPs was revealed. The maximum loading amount and loading efficiency of tangeretin in tangeretin-loaded CD/DBS-NPs (TAN@CD/DBS-NPs) were 17.91 ± 0.03 μg/mg and 83.20 ± 0.15%, respectively. Furthermore, the TAN@CD/DBS-NPs displayed a homogenous distribution and satisfying stability in a series of human microenvironments, including ionic strength (physiological saline), temperature (37 °C), and acidic stomach conditions (pH 2.1). In addition, the maximum retention index of tangeretin in TAN@CD/DBS-NPs reached 99.21 ± 0.17% after a 20-day storage period, suggesting an outstanding effectiveness of CD/DBS-NPs for tangeretin preservation. The prepared nanocarriers were demonstrated to be non-toxic to cells, showing promising potential for applications in the food, pharmaceutical, and cosmetic industries. Image 1 • β-cyclodextrin/debranched starch nanoparticles (CD/DBS-NPs) were fabricated. • Ultrasonication showed crucial impacts on physical properties of CD/DBS-NPs. • CD/DBS-NPs displayed superior loading amount and loading efficiency for tangeretin. • The crystalline structure influenced the stability of tangeretin-loaded CD/DBS-NPs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STARCH
*NANOPARTICLES
*IONIC strength
*CRYSTAL structure
*NANOCARRIERS
Subjects
Details
- Language :
- English
- ISSN :
- 0268005X
- Volume :
- 108
- Database :
- Academic Search Index
- Journal :
- Food Hydrocolloids
- Publication Type :
- Academic Journal
- Accession number :
- 145410953
- Full Text :
- https://doi.org/10.1016/j.foodhyd.2020.106021