Back to Search
Start Over
THE EFFECT OF ANTIGEN DEPRIVATION ON THYMUS-DEPENDENT AND THYMUS- INDEPENDENT LYMPHOCYTES IN THE SMALL INTESTINE OF THE MOUSE.
- Source :
-
Clinical & Experimental Immunology . Dec72, Vol. 12 Issue 4, p477-488. 12p. - Publication Year :
- 1972
-
Abstract
- Isografts of foetal small intestine, implanted under the kidney capsules of adult mice grow normally and, despite the lack of intraluminal antigenic stimulation, are populated by thymus-dependent and thymus-independent lymphocytes. The Peyer's patches in these grafts are very small, lack germinal centres and can be shown to have small thymus-dependent areas. Quantitative intraepithelial lymphocyte counts were carried out in normally sited small intestine of immunologically intact and thymus-deprived mice, and in grafts implanted in intact and thymus-deprived mice. Counts were also performed in a group of neonatally thymectomized and control mice. The results show a significant depletion of intraepithelial lymphocytes in neonatally thymectomized mice, and a profound reduction in numbers of intraepithelial lymphocytes in grafts, deprived of antigen, when compared with normally sited intestine of the same age. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SMALL intestine
*ANTIGENS
*LYMPHOCYTES
*THYMUS
*IMMUNITY
*INTESTINES
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 12
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14541970