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Long-term renal prognosis among patients with primary Sjögren's syndrome and renal involvement: A nationwide matched cohort study.
- Source :
-
Journal of Autoimmunity . Sep2020, Vol. 113, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- The long-term renal outcome in patients with primary Sjögren's syndrome (pSS) remains uncertain. We aimed to determine the absolute incidence and relative risk of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in patients with pSS at the general population level. We performed a retrospective cohort study using a national health insurance database in Taiwan from 2000 to 2013. We calculated the cumulative incidence of CKD and ESRD in our pSS and age-, sex- and entry time-matched control cohorts. Cox regression analyses were used to estimate adjusted hazard ratios (aHRs) after adjusting for comorbidities and medications. Among 17 505 patients with incident pSS, 1008 (5.8%) developed CKD and 38 (0.22%) developed ESRD. Of the 87 525 non-pSS controls, 3173 (3.6%) developed CKD and 256 (0.29%) developed ESRD. The risk of CKD was higher in patients with pSS than in the non-pSS controls (adjusted hazard ratio [HR] 1.49, 95% confidence interval [95% CI] 1.38–1.59). Notably, the risk of ESRD was similar in both pSS and non-pSS cohorts (aHR 0.82, 95% CI 0.58–1.16). Renal prognosis among patients with pSS and renal involvement is good. Although the risk of ESRD did not increase in patients with pSS, a significantly increased risk of CKD was observed in these patients, indicating the need for increased vigilance in regular monitoring for renal complications in patients with pSS. • This nationally representative, population-based cohort study demonstrated that 5.8% of patients with pSS had chronic kidney disease. • Compared to an age- and sex-matched general population cohort, patients with pSS did not have an increased risk of end-stage renal disease. • Regular monitoring of renal function is essential in pSS patients; however, physicians can assure patients that their renal prognosis is good. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHRONIC kidney failure
*NATIONAL health insurance
*COHORT analysis
Subjects
Details
- Language :
- English
- ISSN :
- 08968411
- Volume :
- 113
- Database :
- Academic Search Index
- Journal :
- Journal of Autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 145444026
- Full Text :
- https://doi.org/10.1016/j.jaut.2020.102483