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Age- and sex-specific excess mortality associated with influenza in Shanghai, China, 2010–2015.
- Source :
-
International Journal of Infectious Diseases . Sep2020, Vol. 98, p382-389. 8p. - Publication Year :
- 2020
-
Abstract
- • The mortality burden of influenza has been substantial in Shanghai, especially among the elderly. • Excessive mortality associated with influenza B virus is dominated by B(Yamagata) lineage. • The evidence for sex differences in influenza-associated mortality for respiratory and circulatory diseases is limited. Few studies have explored the different lineages of influenza B viruses, which cause excessive fatalities. This study aimed to estimate age- and sex-specific excessive mortality associated with influenza subtypes/lineages in Shanghai, during 2010–2015. We used quasi-Poisson regression models to fit weekly numbers of deaths from various causes by adjusting long-term trend, seasonal trend, and absolute humidity as confounding factors. The mortality burden associated with influenza subtypes/lineages was estimated by age and sex. The average influenza-associated excessive mortality rate in deaths coded as all-cause was 27.66 (95%CI: 22.30–33.88) per 100,000 person-years. The excessive deaths from six underlying causes in people aged ≥65 years weight heavily. Compared to influenza B(Victoria) lineage, influenza B(Yamagata) lineage had more effect on the influenza-associated disease burden, particularly in patients with respiratory and circulatory diseases. There was no statistical significance of sex in the mortality burden associated with influenza. Disproportionate mortality associated with influenza B virus is dominated by B(Yamagata) lineage in Shanghai, and the evidence for sex differences in the influenza-associated mortality burden for respiratory and circulatory diseases is limited. Improving the vaccination of the elderly and strengthening laboratory-based surveillance of influenza B lineages in Shanghai are needed to reduce this influenza's disease burden. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INFLUENZA
*INFLUENZA B virus
*HUMIDITY
*MORTALITY
*RESPIRATORY diseases
Subjects
Details
- Language :
- English
- ISSN :
- 12019712
- Volume :
- 98
- Database :
- Academic Search Index
- Journal :
- International Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 145517974
- Full Text :
- https://doi.org/10.1016/j.ijid.2020.07.012