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IL-10 from dendritic cells but not from T regulatory cells protects against cisplatin-induced nephrotoxicity.
- Source :
-
PLoS ONE . 9/8/2020, Vol. 15 Issue 9, p1-11. 11p. - Publication Year :
- 2020
-
Abstract
- Interleukin-10 (IL-10), a cytokine with anti-inflammatory effects, is produced by renal parenchymal cells and bone marrow derived cells. Both endogenous and exogenous IL-10 are protective in cisplatin-induced acute kidney injury. However, the source of endogenous IL-10 in cisplatin-induced nephrotoxicity is not clear. Bone marrow chimera experiments in IL10-KO mice indicated that bone marrow derived cells were the primary source of IL-10 in cisplatin nephrotoxicity. Cell specific deletion of IL-10 in T regulatory cells and dendritic cells was accomplished using Foxp3 and CD11c driven cre recombination in IL10flox/flox mice, respectively. Upon treatment with cisplatin, both the IL10flox/flox and the Foxp3YFP-Cre x IL10flox/flox mice developed similar degrees of kidney injury. However, mice with the dendritic cell deletion of IL-10 showed more severe structural and functional changes in the kidney compared to the IL10flox/flox mice. These results indicate that IL-10 from dendritic cells but not from T regulatory cells offers significant endogenous protection against cisplatin induced nephrotoxicity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *B cells
*SUPPRESSOR cells
*DENDRITIC cells
*CISPLATIN
*NEPHROTOXICOLOGY
*BONE marrow
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 145621256
- Full Text :
- https://doi.org/10.1371/journal.pone.0238816