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5′-Nor-3-Deaza-1′,6′-Isoneplanocin, the Synthesis and Antiviral Study.
- Source :
-
Molecules . Sep2020, Vol. 25 Issue 17, p3865-3865. 1p. - Publication Year :
- 2020
-
Abstract
- The arbocyclic nucleosides aristeromycin and neplanocin have been studied as a source for new antiviral agents. A convenient synthesis of C-5′-truncated 3-deaza-1′,6′-isoneplanocin, which combines the features of antiviral candidates 5′-noraristeromycin and 3-deaza-1′,6′-isoneplanocin is reported from (−)-cyclopentenone to give the two C-4′ epimers of 5′-nor-3-deaza isoneplanocin. Antiviral assays showed activity against the JC virus (EC50 = 1.12 µM for (4′R)-8; EC50 = 59.14 µM for (4′S)-7) and inactivity of both compounds against several DNA and RNA viruses. Both compounds lacked cytotoxicity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIVIRAL agents
*JOHN Cunningham virus
*DNA viruses
*RNA viruses
*NUCLEOSIDES
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 145669527
- Full Text :
- https://doi.org/10.3390/molecules25173865