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ANTIGLOBULIN CONSUMPTION TEST WITH SERA FROM PATIENTS WITH MYASTHENIA GRAVIS.
- Source :
-
Clinical & Experimental Immunology . Jul70, Vol. 7 Issue 1, p11-21. 11p. - Publication Year :
- 1970
-
Abstract
- The antiglobulin consumption test was performed with sera from patients with myasthenia gravis, lyophilized skeletal muscle tissue serving as antigen. Incubation of the saline-treated tissue preparation with the antiglobulin serum resulted in a small titre reduction of antiglobulin, indicating in vivo binding of γ-globulins to the tissue (basal consumption). Treatment of the tissue with normal human serum resulted in a greater consumption. This was mediated by γG-globulins, normally present in human sera and with the capacity of binding to skeletal muscle (normal consumption). Sera from twenty-four patients with myasthenia gravis were tested in the anti-globulin consumption test. A positive reaction (pathological consumption) was observed in twelve (50%). Cross-reactions with cardiac muscle and thymus were demonstrated. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COOMBS' test
*MYASTHENIA gravis
*SERUM
*THYMUS
*MYOCARDIUM
*ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 7
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14588539