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Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load.
- Source :
-
CPT: Pharmacometrics & Systems Pharmacology . Sep2020, Vol. 9 Issue 9, p509-514. 6p. - Publication Year :
- 2020
-
Abstract
- We modeled the viral dynamics of 13 untreated patients infected with severe acute respiratory syndrome‐coronavirus 2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than two logs, drug efficacy needs to be > 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6–87% efficacy. They may help control virus if administered very early, but may not have a major effect in severely ill patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VIRAL load
*SARS-CoV-2
*DRUG efficacy
*PEAK load
*TREATMENT effectiveness
Subjects
Details
- Language :
- English
- ISSN :
- 21638306
- Volume :
- 9
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- CPT: Pharmacometrics & Systems Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 145960003
- Full Text :
- https://doi.org/10.1002/psp4.12543