Back to Search
Start Over
C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in human vasculature.
- Source :
-
Canadian Journal of Physiology & Pharmacology . 2020, Vol. 98 Issue 9, p611-617. 7p. - Publication Year :
- 2020
-
Abstract
- To assess the physiological and clinical implications of the C-type natriuretic peptide (CNP)/guanylyl cyclase B (GC-B) system in the human vasculature, we have examined gene expressions of CNP and its receptor, GC-B, in human vascular endothelial cells (ECs) and smooth muscle cells (SMCs) and have also compared the endothelin-1(ET-1)/endothelin receptor-A (ETR-A) and endothelin receptor-B (ETR-B) system in human aortic ECs (HAECs) and vascular SMCs (HSMCs) in vitro. We also examined these gene expressions in human embryonic stem (ES)/induced pluripotent stem cell (iPS)-derived ECs and mural cells (MCs). A little but significant amount of mRNA encoding CNP was detected in both human ES-derived ECs and HAECs. A substantial amount of GC-B was expressed in both ECs (iPS-derived ECs and HAECs) and SMCs (iPS-derived MCs and HSMCs). ET-1 was expressed solely in ECs. ETR-A was expressed in SMCs, while ETR-B was expressed in ECs. These results indicate the existence of a vascular CNP/GC-B system in the human vascular wall, indicating the evidence for clinical implication of the CNP/GC-B system in concert with the ET-1/ETR-A and ETR-B system in the human vasculature. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00084212
- Volume :
- 98
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Canadian Journal of Physiology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 145986777
- Full Text :
- https://doi.org/10.1139/cjpp-2019-0686