A Pre-Test-Post-Test Trial of a Breast Cancer Risk Report for Women in Their 40s.

<bold>Introduction: </bold>Guidelines recommend individualized breast cancer screening and prevention interventions for women in their 40s. Yet, few primary care clinicians assess breast cancer risk.<bold>Study Design: </bold>Pretest-Posttest trial.<bold>Setting/participants: </bold>Women aged 40-49 years were recruited from one large Boston-based academic primary care practice between July 2017 and April 2019.<bold>Intervention: </bold>Participants completed a pretest, received a personalized breast cancer risk report, saw their primary care clinician, and completed a posttest.<bold>Main Outcome Measures: </bold>Using mixed effects models, changes in screening intentions (0-100 scale [0=will not screen to 100=will screen]), mammography knowledge, decisional conflict, and receipt of screening were examined. Analyses were conducted from June 2019 to February 2020.<bold>Results: </bold>Patient (n=337) mean age was 44.1 (SD=2.9) years, 61.4% were non-Hispanic white, and 76.6% were college graduates; 306 (90.5%) completed follow-up (203 with 5-year breast cancer risk <1.1%). Screening intentions declined from pre- to post-visit (79.3 to 68.0, p<0.0001), especially for women with 5-year risk <1.1% (77.2 to 63.3, p<0.0001), but still favored screening. In the 2 years prior, 37.6% had screening mammography compared with 41.8% over a mean 16 months follow-up (p=0.17). Mammography knowledge increased and decisional conflict declined. Eleven (3.3%) women met criteria for breast cancer prevention medications (ten discussed medications with their clinicians), 22 (6.5%) for MRI (19 discussed MRI with their clinician), and 67 (19.8%) for genetic counseling (47 discussed with the clinician).<bold>Conclusions: </bold>Receipt of a personalized breast cancer report was associated with women in their 40s making more-informed and less-conflicted mammography screening decisions and with high-risk women discussing breast cancer prevention interventions with clinicians.<bold>Trial Registration: </bold>This study is registered at www.clinicaltrials.govNCT03180086. [ABSTRACT FROM AUTHOR]