Synthesis and Characterization of Polyrotaxanes Comprising γ‐CDs and Distal Azide‐Terminated PHEMA Using Propargylamine Monosubstituted β‐CDs as End Stoppers.

To highlight whether γ‐cyclodextrins (CDs) facilitate propargylamine monosubstituted β‐CDs (PA‐β‐CDs) as end stoppers to get threaded onto a distal azide terminated poly(2‐hydroxyethylmethacrylate) (PHEMA) homopolymer (PH‐46‐2N3) to create linear and hyperbranched polyrotaxanes (PRs) via the in situ copper‐catalyzed azide/alkyne cycloaddition (CuAAC), PH‐46‐2N3 is self‐assembled with a varying amount of γ‐CDs in water and then subjected the CuAAC with PA‐β‐CDs to end‐cap the resulting γ‐CD‐PHEMA polypseudorotaxanes (PPRs) into the γ‐CD‐PHEMA PRs. It demonstrates that γ‐CDs cannot promote PA‐β‐CDs to be entrapped on the PHEMA chain most likely due to their different cavity size and molecular framework and linear PRs are always formed with up to 29% γ‐CD coverage ratio along the PHEMA axis thereof. [ABSTRACT FROM AUTHOR]