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Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
- Source :
-
Reproductive BioMedicine Online (Elsevier Science) . Oct2020, Vol. 41 Issue 4, p724-728. 5p. - Publication Year :
- 2020
-
Abstract
- This study investigated whether rs1784692 is a risk factor for polycystic ovary syndrome (PCOS) in Han Chinese women. A case-control study was conducted in Han Chinese women, involving 526 PCOS patients and 522 control participants. A TaqMan MGB probe assay was used to genotype the variant rs1784692. Dominant and additive models were employed for genotype–phenotype association analysis in the PCOS and control samples. The minor allele C of rs1784692 is protective against PCOS (odds ratio [OR] 0.556, 95% confidence interval [CI] 0.408–0.759, P = 1.83 × 10–4), even after adjustment for body mass index (BMI) and age (OR adj 0.539, 95% CI 0.391–0.743, P adj = 1.62 × 10–4). Genotype–phenotype analysis of the dominant model showed that mean BMI in the CC+CT group was higher than in the TT group in the PCOS group (27.12 ± 5.82 versus 24.57 ± 4.52, P = 1.0 × 10–3), but not in the control groups, indicating that the minor allele C of rs1784692 associates with BMI in women with PCOS. The mean LH (luteinizing hormone) concentration in the CC+CT group was lower than in the TT group in PCOS and control participants (9.33 ± 5.08 versus 10.93 ± 5.91, P = 0.036; 4.39 ± 1.66 versus 4.89 ± 2.07, P = 0.021). Genotype–phenotype analysis of additive model showed that mean BMI in TC group was higher than in the TT group in PCOS patients compared with control participants (27.14 ± 5.81 versus 24.57 ± 4.52, P = 3.06 × 10–3). The SNP rs1784692 in gene ZBTB16 is protective against PCOS but is associated with increased BMI in Han Chinese women with PCOS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14726483
- Volume :
- 41
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Reproductive BioMedicine Online (Elsevier Science)
- Publication Type :
- Academic Journal
- Accession number :
- 146170100
- Full Text :
- https://doi.org/10.1016/j.rbmo.2020.05.005