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Complementary Capillary System Integrated Microneedles for Autonomously Localized Therapeutics Loading.
- Source :
-
Journal of Microelectromechanical Systems . Oct2020, Vol. 29 Issue 5, p912-917. 6p. - Publication Year :
- 2020
-
Abstract
- This work presents novel solid microneedles (MNs) integrated with a complementary capillary system (CCS) that enables autonomous localization of therapeutic loading. The CCS-MN, realized by 3-D direct-laser-writing (DLW), displays a double-stacked cone structure with a unique top cone consisting of opposing capillary actions: 1) external/internal capillary channels for rapid wicking/loading of liquid contents, respectively, and 2) a hydrophobic doubly-reentrant structure located at the bottom circumference for autonomous liquid confinement at the MN tip. A $2\times2$ CCS-MN array achieved robust skin penetration, withstanding 90 mN force while penetrating $300~\mu \text{m}$ into porcine skin. Significantly enhanced localized liquid loading was confirmed with the integrated CCS-MN when compared to a conventional conical MN, showing a 3.3-fold increase in loaded liquid volume (10 nL vs. 3 nL) - in good agreement with the qualitative staining test on the porcine skin from the delivered dye. Combined, this work provides a unique MN design solution realized by the DLW technology that will significantly advance minimally invasive transdermal delivery platforms. [2020-0166] [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTICS
*SKIN tests
*FLUID mechanics
*SURFACE preparation
Subjects
Details
- Language :
- English
- ISSN :
- 10577157
- Volume :
- 29
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Microelectromechanical Systems
- Publication Type :
- Academic Journal
- Accession number :
- 146359514
- Full Text :
- https://doi.org/10.1109/JMEMS.2020.2999255