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LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way.
- Source :
-
Development (09501991) . Apr2004, Vol. 131 Issue 8, p1663-1677. 15p. 7 Diagrams. - Publication Year :
- 2004
-
Abstract
- Wnt signaling through the canonical β-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/β-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular β-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09501991
- Volume :
- 131
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Development (09501991)
- Publication Type :
- Academic Journal
- Accession number :
- 14636971
- Full Text :
- https://doi.org/10.1242/dev.01117