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Increased mu-opioid receptor expression is associated with reduced disease-free and overall survival in laryngeal squamous cell carcinoma.
- Source :
-
BJA: The British Journal of Anaesthesia . Nov2020, Vol. 125 Issue 5, p722-729. 8p. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Expression of the mu-opioid receptor (MOR) is associated with poor long-term outcomes in various types of cancer. The association between MOR expression and clinical outcomes in laryngeal squamous cell carcinoma (LSCC) is not clear.<bold>Methods: </bold>This retrospective study included patients who underwent laryngectomy for LSCC. The expression pattern of the MOR protein and OPRM1 gene in tumours and corresponding adjacent non-carcinoma specimens was measured. Propensity score matching was used to minimise bias. The primary endpoints were overall survival (OS) and disease-free survival (DFS). The secondary endpoints were intraoperative sufentanil consumption, grade of surgical complications according to the Clavien-Dindo classification, and hospital length of stay.<bold>Results: </bold>A total of 207 LSCC patients were enrolled. After propensity score matching, there was a significant difference in DFS between groups at 1, 3, and 5 yr (60.2% vs 81.2%, P=0.019; 39.4% vs 50.2%, P=0.026; 37.5% vs 42.5%, P=0.023, respectively) in patients with high MOR expression. The OS rates at 1, 3, and 5 yr were significantly lower in the high MOR expression group (81.2% vs 93.2%, P=0.027; 57.7% vs 78.3%, P<0.001; 42.5% vs 60.3%, P<0.001, respectively). The multivariate analysis indicated that high MOR expression was associated with worse DFS and OS (hazard ratio: 1.52, 95% confidence interval: 1.07, 2.25, P=0.034; hazard ratio: 1.42, 95% confidence interval: 1.17, 2.34, P=0.032).<bold>Conclusion: </bold>High MOR expression may be associated with poor prognosis in patients with LSCC, suggesting that MOR could be used as a valuable molecular biomarker to predict prognosis of LSCC patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SQUAMOUS cell carcinoma
*PROGRESSION-free survival
*LARYNGECTOMY
*PROPENSITY score matching
*LENGTH of stay in hospitals
*MULTIVARIATE analysis
*RESEARCH
*ANESTHESIA
*RESEARCH methodology
*CELL receptors
*PROGNOSIS
*RETROSPECTIVE studies
*EVALUATION research
*MEDICAL cooperation
*TREATMENT effectiveness
*COMPARATIVE studies
*KAPLAN-Meier estimator
*SURVIVAL analysis (Biometry)
*BIOLOGICAL assay
*PROBABILITY theory
LARYNGEAL tumors
Subjects
Details
- Language :
- English
- ISSN :
- 00070912
- Volume :
- 125
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- BJA: The British Journal of Anaesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 146396187
- Full Text :
- https://doi.org/10.1016/j.bja.2020.07.051