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Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer's disease scale: development and results from a mapping study.
- Source :
-
Quality of Life Research . Oct2020, p1-13. 1p. - Publication Year :
- 2020
-
Abstract
- <bold>Purpose: </bold>The Quality of Life Alzheimer's Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available.<bold>Methods: </bold>Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error.<bold>Results: </bold>The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset.<bold>Conclusions: </bold>The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09629343
- Database :
- Academic Search Index
- Journal :
- Quality of Life Research
- Publication Type :
- Academic Journal
- Accession number :
- 146460234
- Full Text :
- https://doi.org/10.1007/s11136-020-02670-8