Back to Search
Start Over
PD-1/PD-L1 counterattack alliance: multiple strategies for treating triple-negative breast cancer.
- Source :
-
Drug Discovery Today . Sep2020, Vol. 25 Issue 9, p1762-1771. 10p. - Publication Year :
- 2020
-
Abstract
- • Triple negative breast cancer (TNBC) has high degree of immune cell infiltration. • Anti-programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) antibodies monotherapy has mild respond. • Combination immunotherapy for TNBC has received extensive attention. • Propose multiple strategies to overcome bottleneck in TNBC immunotherapy treatment. Despite extensive research into adjuvant and neoadjuvant chemotherapy, triple-negative breast cancer (TNBC) remains a common breast cancer (BC) subtype with poor prognosis. Given that it has higher immune cell infiltration, theoretically, it should be a protagonist of potential BC immunotherapies. However, only mild responses have been observed in monotherapy with anti-programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) antibodies. In this review, we reappraise PD-1/PD-L1 inhibitor combination immunotherapy and effective experimental compounds, focusing the level of PD-L1 expression, neoantigens, abnormal signaling pathways, and tumor microenvironment signatures, to provide guidance for future clinical trials based on the molecular mechanisms involved. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13596446
- Volume :
- 25
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Drug Discovery Today
- Publication Type :
- Academic Journal
- Accession number :
- 146481326
- Full Text :
- https://doi.org/10.1016/j.drudis.2020.07.006