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Feasibility of a Porcine Arteriovenous Shunt Model for Assessment of Acute Thrombogenicity in Bifurcation Stenting Technique By Optical Coherence Tomography.
- Source :
-
Cardiovascular Revascularization Medicine . Aug2020, Vol. 21 Issue 8, p1000-1005. 6p. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Double kissing (DK) crush stenting has been reported as a superior bifurcation stenting strategy compared to culotte stenting. However, the mechanism associated with the reduction of clinical events by DK crush stenting remains unclear. We therefore investigated the thrombogenicity of DK crush stenting and culotte stenting with both bare-metal stents (BMS) and drug-eluting stents (DES) and the feasibility of a novel porcine arteriovenous shunt model.<bold>Methods: </bold>High-resolution intracoronary imaging with optical coherence tomography (OCT) evaluated the bifurcation stenting models for thrombogenicity.<bold>Results: </bold>All porcine models retained continuous circulation without blood leakage. Thrombus was macroscopically demonstrated around the bifurcation in all settings. The volume of thrombus (mm3) with BMS using DK crush/culotte and DES using DK crush/culotte were 1.38/1.19 and 0.09/0.15, respectively. Culotte stenting had more thrombus in the proximal main branch, and DK crush stenting had more at the bifurcation. Unlike DK crush stenting, culotte stenting showed malapposition in the proximal main branch and bifurcation segments.<bold>Conclusion: </bold>The feasibility of a porcine arteriovenous shunt model to assess thrombogenicity by OCT in bifurcation stenting technique was confirmed. OCT detected less thrombogenicity in DES when used in the bifurcation model when compared to BMS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OPTICAL coherence tomography
*BLOOD circulation
*OPTICAL images
*THROMBOSIS
*FEASIBILITY studies
*MEDICAL equipment
*CAROTID artery surgery
*PROSTHETICS
*PILOT projects
*BIOLOGICAL models
*PREDICTIVE tests
*DRUG-eluting stents
*TIME
*ANIMAL experimentation
*MEDICAL care
*SURGICAL stents
*SWINE
*CARDIOVASCULAR system
*METALS
*JUGULAR vein
Subjects
Details
- Language :
- English
- ISSN :
- 15538389
- Volume :
- 21
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Cardiovascular Revascularization Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 146509472
- Full Text :
- https://doi.org/10.1016/j.carrev.2018.12.025