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Hypervalent iodine mediated radical cyclization of o-(allyloxy)arylaldehydes and N-hydroxyphthalimide (NHPI) under metal-free conditions.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Nov2020, Vol. 61 Issue 45, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- • Hypervalent iodine mediated reactions. • Reactions proceed via radical cyclization mechanism. • Mild and metal-free reaction conditions. An efficient and practical method for the synthesis of substituted chroman-4-ones was developed. The corresponding products can be obtained with moderate to high yields at room temperature. Control experiments suggested that this transformation was likely to proceed via a radical pathway. The preliminary activity test showed that some of the compounds had moderate to high antibacterial activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IODINE
*TEMPERATURE
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 61
- Issue :
- 45
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 146534095
- Full Text :
- https://doi.org/10.1016/j.tetlet.2020.152482