Facile access to chiral β-homoglutamic acid from 3-cyclohexene-carboxylic acid.

A convenient, safe, and effective synthetic protocol for the synthesis of chiral β-homoglutamic acid was described. The strategy started from 3-cyclohexenecarboxylic acid, followed by three steps classic reaction including Curtius Rearrangement, oxidative cleavage of alkene, and debenzylation by catalytic hydrogenation. The chiral β-homoglutamic acid was prepared with a high yield and high enantiomeric excess. [ABSTRACT FROM AUTHOR]